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This household incorporates only one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was discovered to methylate, apart from histone, a lot of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and parts of the TATA binding protein (TBP) complicated, TBP-related elements TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-K (target lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of those substrates 17 , 94 Therefore KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of both histone and non-histone proteins.

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